Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3′-hydroxyacetanilide, in mouse liver
MA Tirmenstein, SD Nelson - Journal of Biological Chemistry, 1989 - ASBMB
Acetaminophen (250 mg/kg) administered intraperitoneally to fasted, phenobarbital-induced
mice produced hepatotoxicity. No hepatotoxicity was observed after the administration of the
regioisomer 3′-hydroxyacetanilide (600 mg/kg). Similar levels of covalent binding to liver
homogenates occurred in mice receiving either acetaminophen or 3′-hydroxyacetanilide at
these doses. However, subcellular fractionation techniques revealed that the
acetaminophen treatment produced greater levels of covalent binding to mitochondrial …
mice produced hepatotoxicity. No hepatotoxicity was observed after the administration of the
regioisomer 3′-hydroxyacetanilide (600 mg/kg). Similar levels of covalent binding to liver
homogenates occurred in mice receiving either acetaminophen or 3′-hydroxyacetanilide at
these doses. However, subcellular fractionation techniques revealed that the
acetaminophen treatment produced greater levels of covalent binding to mitochondrial …