Calmodulin kinase signaling in heart: an intriguing candidate target for therapy of myocardial dysfunction and arrhythmias

ME Anderson - Pharmacology & therapeutics, 2005 - Elsevier
Pharmacology & therapeutics, 2005Elsevier
The multifunctional Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) has
emerged as a proarrhythmic and procardiomyopathic signal in a wide range of structural
heart diseases. This review discusses CaMKII structure and function and recent evidence
implicating CaMKII inhibition as a potential strategy for treating myocardial dysfunction and
arrhythmias in the setting of structural heart disease.
The multifunctional Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) has emerged as a proarrhythmic and procardiomyopathic signal in a wide range of structural heart diseases. This review discusses CaMKII structure and function and recent evidence implicating CaMKII inhibition as a potential strategy for treating myocardial dysfunction and arrhythmias in the setting of structural heart disease.
Elsevier