Background: In resting platelets, endothelial cell specific adhesion molecule (ESAM) is
located in alpha granules, increasing its cell surface expression following platelet activation.
However, the function of ESAM on platelets is unknown. Objective: To determine whether
ESAM has a role in thrombus formation. Methods and results: We found that following
platelet activation ESAM localizes to the junctions between adjacent platelets, suggesting a
role for this protein in contact‐dependent events that regulate thrombus formation. To test …