Induction of experimental ataxic sensory neuronopathy in cats by immunization with purified SGPG
AA Ilyas, Y Gu, MC Dalakas, RH Quarles… - Journal of …, 2008 - Elsevier
IgM paraproteins in about 50% of the patients with neuropathy associated with IgM
gammopathy react with carbohydrate moieties in myelin-associated glycoprotein (MAG) and
in sulfated glucuronic glycolipids (SGGLs) in human peripheral nerves. However, the role of
anti-MAG/SGGL antibodies in the pathogenesis of neuropathy remains unclear. In order to
induce an animal model of neuropathy associated with anti-MAG/SGGL antibodies, cats
were immunized with sulfoglucuronyl paragloboside (SGPG). All four cats immunized with …
gammopathy react with carbohydrate moieties in myelin-associated glycoprotein (MAG) and
in sulfated glucuronic glycolipids (SGGLs) in human peripheral nerves. However, the role of
anti-MAG/SGGL antibodies in the pathogenesis of neuropathy remains unclear. In order to
induce an animal model of neuropathy associated with anti-MAG/SGGL antibodies, cats
were immunized with sulfoglucuronyl paragloboside (SGPG). All four cats immunized with …