Dendritic cells expand Epstein Barr virus specific CD8+ T cell responses more efficiently than EBV transformed B cells
M Subklewe, K Sebelin, A Block, A Meier, A Roukens… - Human immunology, 2005 - Elsevier
Adoptive transfer of Epstein Barr virus (EBV) specific cytotoxic T lymphocytes (CTLs) has
been successfully applied in the treatment of EBV associated post-transplant
lymphoproliferative disease (PTLD). In most studies EBV transformed B cells (LCLs) have
been used for the induction of EBV specific T cell lines. Application of this approach to other
EBV associated tumors is difficult, because LCLs focus T cell expansion toward
immunodominant EBV antigens that are not expressed in EBV associated Hodgkin's …
been successfully applied in the treatment of EBV associated post-transplant
lymphoproliferative disease (PTLD). In most studies EBV transformed B cells (LCLs) have
been used for the induction of EBV specific T cell lines. Application of this approach to other
EBV associated tumors is difficult, because LCLs focus T cell expansion toward
immunodominant EBV antigens that are not expressed in EBV associated Hodgkin's …