Characterization of Epstein-Barr virus Type I variants based on linked polymorphism among EBNA3A,-3B, and-3C genes
I Görzer, HGM Niesters, JJ Cornelissen… - Virus research, 2006 - Elsevier
Latent Epstein-Barr virus (EBV) nuclear antigens (EBNA)-3A,-3B, and-3C are involved in
transcription regulation of both viral and cellular genes. In the present study, we chose
functionally important regions within EBNA3A,-3B, and-3C genes with putative tumorigenic
potential to investigate natural sequence variations among EBV Type I strains circulating in
Europe. Based on the identification of linked EBNA3A,-3B, and-3C sequence patterns, we
defined five EBNA3 variants in addition to the B95. 8 prototype sequence. Phylogenetic …
transcription regulation of both viral and cellular genes. In the present study, we chose
functionally important regions within EBNA3A,-3B, and-3C genes with putative tumorigenic
potential to investigate natural sequence variations among EBV Type I strains circulating in
Europe. Based on the identification of linked EBNA3A,-3B, and-3C sequence patterns, we
defined five EBNA3 variants in addition to the B95. 8 prototype sequence. Phylogenetic …