Adrenomedullin stimulates angiogenic response in cultured human vascular endothelial cells: involvement of the vascular endothelial growth factor receptor 2
D Guidolin, G Albertin, R Spinazzi, E Sorato… - Peptides, 2008 - Elsevier
In recent years, evidence has accumulated that many endogenous peptides play an
important regulatory role in angiogenesis by modulating endothelial cell behavior.
Adrenomedullin (AM), one such factor, was previously shown to exert a clearcut
proangiogenic effect in vitro when tested on specialized human endothelial cells, such as
HUVECs and immortalized endothelial cell lines. In the present study we used normal adult
vascular endothelial cells isolated from human saphenous vein to analyze in vitro the role of …
important regulatory role in angiogenesis by modulating endothelial cell behavior.
Adrenomedullin (AM), one such factor, was previously shown to exert a clearcut
proangiogenic effect in vitro when tested on specialized human endothelial cells, such as
HUVECs and immortalized endothelial cell lines. In the present study we used normal adult
vascular endothelial cells isolated from human saphenous vein to analyze in vitro the role of …