Intranasal insulin improves cognition and modulates β-amyloid in early AD

MS Dhamoon, JM Noble - Neurology, 2009 - AAN Enterprises
Neurology, 2009AAN Enterprises
Interestingly, the NIH Laboratory where I spent my career bore the name “Slow, Latent, and
Temperate Viruses of the CNS,” and for quite some time it looked as though a “slow virus”
might be at the root of the problem (similar to the JC virus that causes progressive multifocal
leukoencephalopathy). However, as new observations were made, 6 the concept of a slow
virus became less and less tenable, at least as the sole cause of disease, which certainly
can no longer be seriously considered. Regarding the Spiroplasma hypothesis, the failure of …
Interestingly, the NIH Laboratory where I spent my career bore the name “Slow, Latent, and Temperate Viruses of the CNS,” and for quite some time it looked as though a “slow virus” might be at the root of the problem (similar to the JC virus that causes progressive multifocal leukoencephalopathy). However, as new observations were made, 6 the concept of a slow virus became less and less tenable, at least as the sole cause of disease, which certainly can no longer be seriously considered. Regarding the Spiroplasma hypothesis, the failure of a blinded study of rRNA species to detect any footprint of Spiroplasma in scrapie-infected hamster brain7 laid it to rest, unless one holds that the cause of scrapie is different from that of other prion diseases, an equally untenable proposition.
American Academy of Neurology