[HTML][HTML] Oncogenic Ras induces p19ARF and growth arrest in mouse embryo fibroblasts lacking p21Cip1 and p27Kip1 without activating cyclin D-dependent kinases
Oncogenic Ras induces two products of theINK4a/ARF tumor suppressor locus (p16 INK4a
and p19 ARF) in primary human and rodent fibroblasts, ultimately leading to a permanent
state of cell cycle arrest resembling replicative senescence. Whereas p16 INK4a
antagonizes the activities of cyclin D-dependent kinases, p19 ARF activates the p53
transcription factor. Immortalized rodent fibroblast cell lines that lack INK4a/ARF function,
ARF alone, or p53 are resistant to the growth inhibitory effects of oncogenic Ras and instead …
and p19 ARF) in primary human and rodent fibroblasts, ultimately leading to a permanent
state of cell cycle arrest resembling replicative senescence. Whereas p16 INK4a
antagonizes the activities of cyclin D-dependent kinases, p19 ARF activates the p53
transcription factor. Immortalized rodent fibroblast cell lines that lack INK4a/ARF function,
ARF alone, or p53 are resistant to the growth inhibitory effects of oncogenic Ras and instead …