The study of chronic brain diseases including Alzheimer's disease in patients is typically
limited to brain imaging or psychometric testing. Given the epidemic rise and insufficient
knowledge about pathological pathways in sporadic Alzheimer's disease, new tools are
required to identify the molecular changes underlying this disease. We hypothesize that
levels of specific secreted cellular signaling proteins in cerebrospinal fluid or plasma
correlate with pathological changes in the Alzheimer's disease brain and can thus be used …