Cell mediators of inflammation in the Alzheimer disease brain
H Akiyama, T Arai, H Kondo, E Tanno… - Alzheimer Disease & …, 2000 - journals.lww.com
Lesions of Alzheimer disease are associated with low-grade but sustained inflammatory
responses. Activated microglia agglomerate in the center of senile plaques. Reactive
astrocytes marginate the amyloid β-protein (Aβ) deposits and extend their processes toward
the center of plaques. Both microglia and astrocytes are known to secrete a wide variety of
molecules involved in inflammation and are potential sources of proinflammatory elements
in the brain. Dystrophic neurites occur in senile plaques with such glial reactions, suggesting …
responses. Activated microglia agglomerate in the center of senile plaques. Reactive
astrocytes marginate the amyloid β-protein (Aβ) deposits and extend their processes toward
the center of plaques. Both microglia and astrocytes are known to secrete a wide variety of
molecules involved in inflammation and are potential sources of proinflammatory elements
in the brain. Dystrophic neurites occur in senile plaques with such glial reactions, suggesting …