Lack of correlation between cortical demyelination and white matter pathologic changes in multiple sclerosis
L Bö, JJG Geurts, P van der Valk, C Polman… - Archives of …, 2007 - jamanetwork.com
Background Histopathologic studies have shown that subpial cortical demyelination is
extensive in chronic multiple sclerosis (MS). Objective To study whether subpial cortical
demyelination in MS is associated with focal or diffuse white matter (WM) pathologic features
on magnetic resonance imaging (MR imaging). Design Comparison of postmortem MR
imaging findings with histopathologic findings. Setting Brain donations from a general
community. Patients Three patients with MS with extensive cortical demyelination and 3 …
extensive in chronic multiple sclerosis (MS). Objective To study whether subpial cortical
demyelination in MS is associated with focal or diffuse white matter (WM) pathologic features
on magnetic resonance imaging (MR imaging). Design Comparison of postmortem MR
imaging findings with histopathologic findings. Setting Brain donations from a general
community. Patients Three patients with MS with extensive cortical demyelination and 3 …