Serial contrast-enhanced MR in patients with multiple sclerosis and varying levels of disability.

M Filippi, P Rossi, A Campi… - American Journal …, 1997 - Am Soc Neuroradiology
M Filippi, P Rossi, A Campi, B Colombo, C Pereira, G Comi
American Journal of Neuroradiology, 1997Am Soc Neuroradiology
PURPOSE To compare the rates of enhancement and changes in lesion burden in patients
with multiple sclerosis (MS) and varying levels of disability. METHODS Monthly enhanced
MR images of the brain were obtained for 6 months from seven patients with mildly disabling
relapsing-remitting MS and from seven patients with secondary progressive MS and severe
disability. At entry and 1 year later, two unenhanced T2-weighted images of the brain were
also obtained. RESULTS Despite the fact that both groups had clinically active disease and …
PURPOSE
To compare the rates of enhancement and changes in lesion burden in patients with multiple sclerosis (MS) and varying levels of disability.
METHODS
Monthly enhanced MR images of the brain were obtained for 6 months from seven patients with mildly disabling relapsing-remitting MS and from seven patients with secondary progressive MS and severe disability. At entry and 1 year later, two unenhanced T2-weighted images of the brain were also obtained.
RESULTS
Despite the fact that both groups had clinically active disease and had similar increases in unenhanced MR lesion load, the total number of enhancing lesions was 239 in patients with relapsing-remitting MS (42 on the baseline images, 151 new and 46 persistent during follow-up) (average number of lesions per patient per year was 68) and 21 in those with secondary progressive MS (five on the baseline images, 13 new, and three persistent during follow-up) (average number of lesions per patients per year was seven).
CONCLUSION
Our data indicate that the rate of enhancement significantly decreases in the more advanced phases of MS. This is important when planning clinical trials, and suggests that mechanisms underlying lesion formation might be dissimilar in different MS patient groups.
American Journal of Neuroradiology