Glutamate release from astrocytes in physiological conditions and in neurodegenerative disorders characterized by neuroinflammation
S Vesce, D Rossi, L Brambilla, A Volterra - International review of …, 2007 - Elsevier
Although glial cells have been traditionally viewed as supportive partners of neurons,
studies of the last 20 years demonstrate that astrocytes possess functional receptors for
neurotransmitters and other signaling molecules and respond to their stimulation via release
of chemical transmitters (called gliotransmitters) such as glutamate, ATP, and d‐serine.
Notably, astrocytes react to synaptically released neurotransmitters with intracellular calcium
([Ca 2+] i) elevations, which result in the release of glutamate via regulated exocytosis and …
studies of the last 20 years demonstrate that astrocytes possess functional receptors for
neurotransmitters and other signaling molecules and respond to their stimulation via release
of chemical transmitters (called gliotransmitters) such as glutamate, ATP, and d‐serine.
Notably, astrocytes react to synaptically released neurotransmitters with intracellular calcium
([Ca 2+] i) elevations, which result in the release of glutamate via regulated exocytosis and …