Histamine and histamine-N-methyltransferase in the CSF of patients with multiple sclerosis
L Tuomisto, H Kilpeläinen, P Riekkinen - Agents and actions, 1983 - Springer
L Tuomisto, H Kilpeläinen, P Riekkinen
Agents and actions, 1983•SpringerThe CSF of twenty-six patients with multiple sclerosis (MS) and of twelve control persons
was analysed for histamine and histamine-N-methyltransferase (HMT) activity. Both in
patients with remitting and progressive type of disease the histamine level was about 60%
higher than in the controls. On the other hand in both groups of patients the HMT activity was
significantly lower (32% and 40% respectively) than that of controls. These results suggest
an altered histamine metabolism in MS. This might be associated with the immune reaction …
was analysed for histamine and histamine-N-methyltransferase (HMT) activity. Both in
patients with remitting and progressive type of disease the histamine level was about 60%
higher than in the controls. On the other hand in both groups of patients the HMT activity was
significantly lower (32% and 40% respectively) than that of controls. These results suggest
an altered histamine metabolism in MS. This might be associated with the immune reaction …
Abstract
The CSF of twenty-six patients with multiple sclerosis (MS) and of twelve control persons was analysed for histamine and histamine-N-methyltransferase (HMT) activity. Both in patients with remitting and progressive type of disease the histamine level was about 60% higher than in the controls. On the other hand in both groups of patients the HMT activity was significantly lower (32% and 40% respectively) than that of controls. These results suggest an altered histamine metabolism in MS. This might be associated with the immune reaction in MS brain.
Springer