Multiple sclerosis flares associated with recombinant granulocyte colony-stimulating factor
Neurology, 2000•AAN Enterprises
Article abstract Four of 10 patients who were enrolled on protocols of high-dose
immunosuppression with peripheral blood stem cell rescue for MS experienced neurologic
worsening while receiving recombinant human granulocyte colony-stimulating factor. There
was improvement when methylprednisolone was given to three of the patients, but one
patient died of respiratory failure. The mechanism of the neurologic worsening is uncertain.
immunosuppression with peripheral blood stem cell rescue for MS experienced neurologic
worsening while receiving recombinant human granulocyte colony-stimulating factor. There
was improvement when methylprednisolone was given to three of the patients, but one
patient died of respiratory failure. The mechanism of the neurologic worsening is uncertain.
Article abstract Four of 10 patients who were enrolled on protocols of high-dose immunosuppression with peripheral blood stem cell rescue for MS experienced neurologic worsening while receiving recombinant human granulocyte colony-stimulating factor. There was improvement when methylprednisolone was given to three of the patients, but one patient died of respiratory failure. The mechanism of the neurologic worsening is uncertain.
American Academy of Neurology