P/Q type calcium-channel antibodies in paraneoplastic cerebellar degeneration with lung cancer
F Graus, B Lang, P Pozo-Rosich, A Saiz… - Neurology, 2002 - AAN Enterprises
F Graus, B Lang, P Pozo-Rosich, A Saiz, R Casamitjana, A Vincent
Neurology, 2002•AAN EnterprisesRaised levels of P/Q type voltage-gated calcium-channel (VGCC) antibodies were found in
16 (41%) of 39 patients with paraneoplastic cerebellar degeneration (PCD) and Hu
antibodies were found in nine (23%). Seven of the 16 VGCC antibody-positive patients had
Lambert–Eaton myasthenic syndrome (LEMS). Seven of 15 CSF samples had VGCC
antibodies, with evidence of intrathecal synthesis in four. VGCC antibodies should be looked
for in PCD, even if there are no symptoms of LEMS, and may be related to the cerebellar …
16 (41%) of 39 patients with paraneoplastic cerebellar degeneration (PCD) and Hu
antibodies were found in nine (23%). Seven of the 16 VGCC antibody-positive patients had
Lambert–Eaton myasthenic syndrome (LEMS). Seven of 15 CSF samples had VGCC
antibodies, with evidence of intrathecal synthesis in four. VGCC antibodies should be looked
for in PCD, even if there are no symptoms of LEMS, and may be related to the cerebellar …
Raised levels of P/Q type voltage-gated calcium-channel (VGCC) antibodies were found in 16 (41%) of 39 patients with paraneoplastic cerebellar degeneration (PCD) and Hu antibodies were found in nine (23%). Seven of the 16 VGCC antibody-positive patients had Lambert–Eaton myasthenic syndrome (LEMS). Seven of 15 CSF samples had VGCC antibodies, with evidence of intrathecal synthesis in four. VGCC antibodies should be looked for in PCD, even if there are no symptoms of LEMS, and may be related to the cerebellar dysfunction.
American Academy of Neurology