Trisomy 4 associated with double minute chromosomes and MYC amplification in acute myeloblastic leukemia
A Receveur, J Ong, L Merlin, Z Azgui, H Merle-Béral… - Annales de …, 2004 - Elsevier
A case of de novo acute myeloblastic leukemia (AML) M2, with trisomy 4 and double minute
(dmin) chromosomes is reported. Amplification of the MYC gene ascertained by FISH was
associated with dmin. A review of the literature of trisomy 4-dmin-associated AML shows that
this entity preferentially occurs in elderly women and is not always associated with
previously identified exposition to mutagens.
(dmin) chromosomes is reported. Amplification of the MYC gene ascertained by FISH was
associated with dmin. A review of the literature of trisomy 4-dmin-associated AML shows that
this entity preferentially occurs in elderly women and is not always associated with
previously identified exposition to mutagens.