Overexpression of BUBR1 is associated with chromosomal instability in bladder cancer
Y Yamamoto, H Matsuyama, Y Chochi, M Okuda… - Cancer genetics and …, 2007 - Elsevier
BUBR1, a mitotic checkpoint protein, is a key component of the mitotic spindle checkpoint
machinery. Defective BUBR1 has been proposed to contribute to chromosomal instability
(CIN). To elucidate the relationship of BUBR1 expression with CIN, expression of BUBR1,
numbers of centrosomes, numerical aberrations of chromosomes, and DNA ploidy were
examined, and BUBR1 expression status was compared with clinicopathological
parameters in 104 human urothelial bladder carcinomas. Expression of BUBR1 and …
machinery. Defective BUBR1 has been proposed to contribute to chromosomal instability
(CIN). To elucidate the relationship of BUBR1 expression with CIN, expression of BUBR1,
numbers of centrosomes, numerical aberrations of chromosomes, and DNA ploidy were
examined, and BUBR1 expression status was compared with clinicopathological
parameters in 104 human urothelial bladder carcinomas. Expression of BUBR1 and …