[HTML][HTML] Identification of MCM4 as a target of the DNA replication block checkpoint system
Y Ishimi, Y Komamura-Kohno, HJ Kwon… - Journal of Biological …, 2003 - ASBMB
Inhibition of the progression of DNA replication prevents further initiation of DNA replication
and allows cells to maintain arrested replication forks, but the proteins that are targets of the
replication checkpoint system remain to be identified. We report here that human MCM4, a
subunit of the putative DNA replicative helicase, is extensively phosphorylated in HeLa cells
when they are incubated in the presence of inhibitors of DNA synthesis or are exposed to
UV irradiation. The data presented here indicate that the consecutive actions of ATR-CHK1 …
and allows cells to maintain arrested replication forks, but the proteins that are targets of the
replication checkpoint system remain to be identified. We report here that human MCM4, a
subunit of the putative DNA replicative helicase, is extensively phosphorylated in HeLa cells
when they are incubated in the presence of inhibitors of DNA synthesis or are exposed to
UV irradiation. The data presented here indicate that the consecutive actions of ATR-CHK1 …