A patient with simultaneous absence of “classical” natural killer cells (CD3−, CD16+, and NKH1+) and expansion of CD3+, CD4−, CD8−, NKH1+ subset
ZK Ballas, JM Turner, DA Turner, EA Goetzman… - Journal of allergy and …, 1990 - Elsevier
The clinical manifestations of putative natural killer (NK) cell deficiency are not well-known
but theoretically should include recurrent tumors and systemic viral infections. In this article,
we discuss a patient with recurrent candylomata, vulvar and cervical carcinoma in situ,
pulmonary infiltrates of unknown significance, and a hypercoagulable state. This patient has
a dramatic persistent deficiency in her circulating “classic” NK cells (CD3−, CD16+, NKH1+)
and a simultaneous persistent expansion of a normally minor lymphocyte cell subset (CD3+ …
but theoretically should include recurrent tumors and systemic viral infections. In this article,
we discuss a patient with recurrent candylomata, vulvar and cervical carcinoma in situ,
pulmonary infiltrates of unknown significance, and a hypercoagulable state. This patient has
a dramatic persistent deficiency in her circulating “classic” NK cells (CD3−, CD16+, NKH1+)
and a simultaneous persistent expansion of a normally minor lymphocyte cell subset (CD3+ …