[HTML][HTML] ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage
N Taira, H Yamamoto, T Yamaguchi, Y Miki… - Journal of biological …, 2010 - ASBMB
The tumor suppressor p53 is a transcription factor that regulates cell cycle, DNA repair,
senescence, and apoptosis in response to DNA damage. Phosphorylation of p53 at Ser-46
is indispensable for the commitment to apoptotic cell death. A previous study has shown that
upon exposure to genotoxic stress, DYRK2 translocates into the nucleus and
phosphorylates p53 at Ser-46, thereby inducing apoptosis. However, less is known about
mechanisms responsible for intracellular control of DYRK2. Here we show the functional …
senescence, and apoptosis in response to DNA damage. Phosphorylation of p53 at Ser-46
is indispensable for the commitment to apoptotic cell death. A previous study has shown that
upon exposure to genotoxic stress, DYRK2 translocates into the nucleus and
phosphorylates p53 at Ser-46, thereby inducing apoptosis. However, less is known about
mechanisms responsible for intracellular control of DYRK2. Here we show the functional …