[PDF][PDF] Phosphatases at the heart of FoxO metabolic control
ML Tremblay, V Giguère - Cell metabolism, 2008 - cell.com
Cell metabolism, 2008•cell.com
FoxO transcription factors contribute to cardiac muscle remodeling and insulin signaling, but
how they link insulin resistance and maladaptive heart hypertrophy remains unknown. A
new study by Ni et al.(2007) shows that sustained activation of FoxO1 or FoxO3 in
cardiomyocytes selectively enhances the activity of Akt/PKB and reduces insulin signaling
through inhibition of calcineurin and PP2A.
how they link insulin resistance and maladaptive heart hypertrophy remains unknown. A
new study by Ni et al.(2007) shows that sustained activation of FoxO1 or FoxO3 in
cardiomyocytes selectively enhances the activity of Akt/PKB and reduces insulin signaling
through inhibition of calcineurin and PP2A.
FoxO transcription factors contribute to cardiac muscle remodeling and insulin signaling, but how they link insulin resistance and maladaptive heart hypertrophy remains unknown. A new study by Ni et al. (2007) shows that sustained activation of FoxO1 or FoxO3 in cardiomyocytes selectively enhances the activity of Akt/PKB and reduces insulin signaling through inhibition of calcineurin and PP2A.
cell.com