[HTML][HTML] b-series Ganglioside deficiency exhibits no definite changes in the neurogenesis and the sensitivity to Fas-mediated apoptosis but impairs regeneration of the …
M Okada, M Itoh, M Haraguchi, T Okajima… - Journal of Biological …, 2002 - ASBMB
The polymorphic carbohydrate structures of gangliosides play regulatory roles. In particular,
b-series gangliosides, all of which contain α-2, 8 sialic acids, have been considered to be
critical in various biological events such as adhesion, toxin binding, neurite extension, cell
growth, and apoptosis. To clarify the physiological functions of b-series gangliosides in vivo,
we have established a gene knockout mouse of GD3 synthase. Although all b-series
structures were deleted in the mutant mice, they showed an almost complete nervous tissue …
b-series gangliosides, all of which contain α-2, 8 sialic acids, have been considered to be
critical in various biological events such as adhesion, toxin binding, neurite extension, cell
growth, and apoptosis. To clarify the physiological functions of b-series gangliosides in vivo,
we have established a gene knockout mouse of GD3 synthase. Although all b-series
structures were deleted in the mutant mice, they showed an almost complete nervous tissue …