Mitogenic signaling via platelet-derived growth factor β in metanephric mesenchymal cells
B Wagner, JM Ricono, Y Gorin, K Block… - Journal of the …, 2007 - journals.lww.com
Mice deficient in either platelet-derived growth factor (PDGF) B chain or PDGF receptor
(PDGFR) β lack mesangial cells. PDGF stimulates proliferation and migration of metanephric
mesenchymal cells, from which mesangial cells are derived. Binding of PDGF to PDGFR-β
induces autophosphorylation at specific tyrosine residues and activates various effector
proteins, including phosphatidylinositol-3-kinase (PI3-K). This study explored the role of PI 3-
K and reactive oxygen species (ROS) in PDGF-mediated signaling using cells established …
(PDGFR) β lack mesangial cells. PDGF stimulates proliferation and migration of metanephric
mesenchymal cells, from which mesangial cells are derived. Binding of PDGF to PDGFR-β
induces autophosphorylation at specific tyrosine residues and activates various effector
proteins, including phosphatidylinositol-3-kinase (PI3-K). This study explored the role of PI 3-
K and reactive oxygen species (ROS) in PDGF-mediated signaling using cells established …