[HTML][HTML] Transcriptional activation of the human leptin gene in response to hypoxia: involvement of hypoxia-inducible factor 1
G Ambrosini, AK Nath, MR Sierra-Honigmann… - Journal of Biological …, 2002 - ASBMB
In addition to having a major role in energy homeostasis, leptin is emerging as a pleiotropic
cytokine with multiple physiological effector functions. The recently discovered
proangiogenic activity of leptin suggested the hypothesis that its production might be
regulated by hypoxia, as are other angiogenic factors. To examine this proposal, the
expression of leptin protein and mRNA was measured and found to be markedly up-
regulated in response to ambient or chemical hypoxia (upon exposure to desferrioxamine or …
cytokine with multiple physiological effector functions. The recently discovered
proangiogenic activity of leptin suggested the hypothesis that its production might be
regulated by hypoxia, as are other angiogenic factors. To examine this proposal, the
expression of leptin protein and mRNA was measured and found to be markedly up-
regulated in response to ambient or chemical hypoxia (upon exposure to desferrioxamine or …