[HTML][HTML] The mouse obese gene: Genomic organization, promoter activity, and activation by ccaat/enhancer-binding protein α
The obese gene product, leptin, regulates adiposity. Mice homozygous for a nonfunctional
obese gene become massively obese and develop diabetes mellitus due to overeating and
increased metabolic efficiency. The cDNA sequence of obese was recently reported (Zhang,
Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., and Friedman, JL (1994) Nature 372,
425-432; Correction:(1995 Nature 374, 479). We have determined the genomic organization
of the 5′ end of the mouse obese gene. The coding sequence is in exons 2 and 3. A single …
obese gene become massively obese and develop diabetes mellitus due to overeating and
increased metabolic efficiency. The cDNA sequence of obese was recently reported (Zhang,
Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., and Friedman, JL (1994) Nature 372,
425-432; Correction:(1995 Nature 374, 479). We have determined the genomic organization
of the 5′ end of the mouse obese gene. The coding sequence is in exons 2 and 3. A single …