[HTML][HTML] Sequence analysis of heparan sulfate epitopes with graded affinities for fibroblast growth factors 1 and 2
J Kreuger, M Salmivirta, L Sturiale… - Journal of Biological …, 2001 - ASBMB
Proteins that belong to the fibroblast growth factor (FGF) family regulate proliferation,
migration, and differentiation of many cell types. Several FGFs, including the prototype
factors FGF-1 and FGF-2, depend on interactions with heparan sulfate (HS) proteoglycans
for activity. We have assessed tissue-derived HS fragments for binding to FGF-1 and FGF-2
to identify the authentic saccharide motifs required for interactions. Sequence information on
a range of N-sulfated HS octasaccharides spanning from low to high affinity for FGF-1 was …
migration, and differentiation of many cell types. Several FGFs, including the prototype
factors FGF-1 and FGF-2, depend on interactions with heparan sulfate (HS) proteoglycans
for activity. We have assessed tissue-derived HS fragments for binding to FGF-1 and FGF-2
to identify the authentic saccharide motifs required for interactions. Sequence information on
a range of N-sulfated HS octasaccharides spanning from low to high affinity for FGF-1 was …