BACKGROUND: Reports of genetic analyses on pediatric gliomas are few, and those tumors
have been far less characterized than adult gliomas. OBJECTIVE: To characterize the
genetic and biological features of pediatric gliomas. METHODS: We investigated 23
pediatric nonependymal, nonpilocytic gliomas for chromosomal copy number aberrations
(CNAs) by comparative genomic hybridization (CGH), mutations of isocitrate dehydrogenase
(IDH) genes by direct sequencing, and proliferative activity and expression of O 6 …