Vascular smooth muscle cell apoptosis in abdominal aortic aneurysms
RW Thompson, S Liao, JA Curci - Coronary artery disease, 1997 - journals.lww.com
Apoptosis is a naturally occurring mechanism of cell death that plays an important role in
both normal and pathological remodeling of the vessel wall. Abdominal aortic aneurysms
(AAA) represent a unique and dramatic example of vessel wall remodeling characterized by
degeneration of the elastic media. Although much attention has been focused on the
proteolytic mechanisms that underlie elastin and collagen degradation in AAA, recent
studies suggest that depletion of medial smooth muscle cells (SMC) makes an important …
both normal and pathological remodeling of the vessel wall. Abdominal aortic aneurysms
(AAA) represent a unique and dramatic example of vessel wall remodeling characterized by
degeneration of the elastic media. Although much attention has been focused on the
proteolytic mechanisms that underlie elastin and collagen degradation in AAA, recent
studies suggest that depletion of medial smooth muscle cells (SMC) makes an important …