A novel dendritic cell subset involved in tumor immunosurveillance

J Taieb, N Chaput, C Ménard, L Apetoh, E Ullrich… - Nature medicine, 2006 - nature.com
J Taieb, N Chaput, C Ménard, L Apetoh, E Ullrich, M Bonmort, M Péquignot, N Casares…
Nature medicine, 2006nature.com
Abstract The interferon (IFN)-γ–induced TRAIL effector mechanism is a vital component of
cancer immunosurveillance by natural killer (NK) cells in mice,. Here we show that the main
source of IFN-γ is not the conventional NK cell but a subset of B220+ Ly6C− dendritic cells,
which are atypical insofar as they express NK cell-surface molecules. Upon contact with a
variety of tumor cells that are poorly recognized by NK cells, B220+ NK1. 1+ dendritic cells
secrete high levels of IFN-γ and mediate TRAIL-dependent lysis of tumor cells. Adoptive …
Abstract
The interferon (IFN)-γ–induced TRAIL effector mechanism is a vital component of cancer immunosurveillance by natural killer (NK) cells in mice,. Here we show that the main source of IFN-γ is not the conventional NK cell but a subset of B220+Ly6C dendritic cells, which are atypical insofar as they express NK cell-surface molecules. Upon contact with a variety of tumor cells that are poorly recognized by NK cells, B220+NK1.1+ dendritic cells secrete high levels of IFN-γ and mediate TRAIL-dependent lysis of tumor cells. Adoptive transfer of these IFN-producing killer dendritic cells (IKDCs) into tumor-bearing Rag2−/−Il2rg−/− mice prevented tumor outgrowth, whereas transfer of conventional NK cells did not. In conclusion, we identified IKDCs as pivotal sensors and effectors of the innate antitumor immune response.
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