Effect of dipyridamole on kidney function in cirrhosis
J Llach, P Ginès, V Arroyo, JM Salmerón, A Ginès… - Hepatology, 1993 - journals.lww.com
Adenosine is a potent endogenous renal vasoconstrictor. To investigate the sensitivity of the
renal circulation to adenosine in cirrhosis, we evaluated kidney function and vasoactive
hormones in 20 patients with cirrhosis before and after administration of dipyridamole (0.4
mg/kg, intravenously), a drug that increases extracellular levels of adenosine. In patients
with ascites and increased plasma renin activity (6.9±4.0 ng/ml hr [mean±SD])(n= 7),
dipyridamole induced marked reductions in renal plasma flow (from 623±294 to 374±188 …
renal circulation to adenosine in cirrhosis, we evaluated kidney function and vasoactive
hormones in 20 patients with cirrhosis before and after administration of dipyridamole (0.4
mg/kg, intravenously), a drug that increases extracellular levels of adenosine. In patients
with ascites and increased plasma renin activity (6.9±4.0 ng/ml hr [mean±SD])(n= 7),
dipyridamole induced marked reductions in renal plasma flow (from 623±294 to 374±188 …