Role of oxidized low density lipoprotein in atherogenesis.
JL Witztum, D Steinberg - The Journal of clinical …, 1991 - Am Soc Clin Investig
JL Witztum, D Steinberg
The Journal of clinical investigation, 1991•Am Soc Clin InvestigEvidence to support an important role of oxidative modification in mediating the
atherogenicity of LDL continues to grow. New hypotheses suggest mechanisms by which Ox-
LDL or products of Ox-LDL can affect many components of the atherogenic process,
including vasomotor properties and thrombosis, as well as lesion initiation and progression
itself. These ideas suggest new approaches, that in combination with lowering of plasma
cholesterol, could lead to the prevention of atherosclerosis and its complications.
atherogenicity of LDL continues to grow. New hypotheses suggest mechanisms by which Ox-
LDL or products of Ox-LDL can affect many components of the atherogenic process,
including vasomotor properties and thrombosis, as well as lesion initiation and progression
itself. These ideas suggest new approaches, that in combination with lowering of plasma
cholesterol, could lead to the prevention of atherosclerosis and its complications.
Evidence to support an important role of oxidative modification in mediating the atherogenicity of LDL continues to grow. New hypotheses suggest mechanisms by which Ox-LDL or products of Ox-LDL can affect many components of the atherogenic process, including vasomotor properties and thrombosis, as well as lesion initiation and progression itself. These ideas suggest new approaches, that in combination with lowering of plasma cholesterol, could lead to the prevention of atherosclerosis and its complications.
The Journal of Clinical Investigation