[HTML][HTML] A new method for measurement of total plasma PCSK9: clinical applications

G Dubuc, M Tremblay, G Paré, H Jacques… - Journal of lipid …, 2010 - ASBMB
The proprotein convertase subtilisin kexin-9 (PCSK9) circulates in plasma as mature and
furin-cleaved forms. A polyclonal antibody against human PCSK9 was used to develop an
ELISA that measures total plasma PCSK9 rather than only the mature form. A cross-
sectional study evaluated plasma levels in normal (n= 254) and hypercholesterolemic (n=
200) subjects treated or untreated with statins or statin plus ezetimibe. In controls, mean
plasma PCSK9 (89.5±31.9 ng/ml) correlated positively with age, total cholesterol, LDL …