Effect of interferon alpha on hepatitis B virus replication and gene expression in transiently transfected human hepatoma cells
A Rang, S Günther, H Will - Journal of hepatology, 1999 - Elsevier
Background/Aims: Chronic hepatitis B virus (HBV) infection is predominantly treated with
interferon alpha (IFNα), which results in efficient reduction of the viral load only in 10–20% of
treated patients. The mechanisms induced by IFNα resulting in reduction of viremia in
responding patients are unknown. The aim of this study was to characterize HBV-specific
IFNα-inducedintracellular inhibitory mechanisms and IFNα-sensitive HBV targets. Methods:
To determine the antiviral activity, cells transiently transfected with HBV DNA were treated …
interferon alpha (IFNα), which results in efficient reduction of the viral load only in 10–20% of
treated patients. The mechanisms induced by IFNα resulting in reduction of viremia in
responding patients are unknown. The aim of this study was to characterize HBV-specific
IFNα-inducedintracellular inhibitory mechanisms and IFNα-sensitive HBV targets. Methods:
To determine the antiviral activity, cells transiently transfected with HBV DNA were treated …