[HTML][HTML] Mast cell and neutrophil peptidases attack an inactivation segment in hepatocyte growth factor to generate NK4-like antagonists
WW Raymond, AC Cruz, GH Caughey - Journal of Biological Chemistry, 2006 - ASBMB
Hepatocyte growth factor (HGF) is a plasminogen-like protein with an α chain linked to a
trypsin-like β chain without peptidase activity. The interaction of HGF with c-met, a receptor
tyrosine kinase expressed by many cells, is important in cell growth, migration, and
formation of endothelial and epithelial tubes. Stimulation of c-met requires two-chain,
disulfide-linked HGF. Portions of an α chain containing an N-terminal segment and four
kringle domains (NK4) antagonize HGF activity. Until now, no physiological pathway for …
trypsin-like β chain without peptidase activity. The interaction of HGF with c-met, a receptor
tyrosine kinase expressed by many cells, is important in cell growth, migration, and
formation of endothelial and epithelial tubes. Stimulation of c-met requires two-chain,
disulfide-linked HGF. Portions of an α chain containing an N-terminal segment and four
kringle domains (NK4) antagonize HGF activity. Until now, no physiological pathway for …