Compensatory role of Langerhans cells and langerin-positive dermal dendritic cells in the sensitization phase of murine contact hypersensitivity
At present, there are 2 types of LC ablation murine models. The first uses mice that express
enhanced green fluorescent protein (eGFP) fused with a diphtheria toxin (DT) receptor
(DTR) under the control of the langerin promoter, which are known as langerineGFP-DTR
mice, 3, 4 and langerin-DTR mice. 6-8 In these knock-in mice, both LCs and langerin-
positive dDCs are detected based on their eGFP expression, and both are completely
depleted by administration of DT. Once depleted, LCs do not repopulate for at least 4 weeks …
enhanced green fluorescent protein (eGFP) fused with a diphtheria toxin (DT) receptor
(DTR) under the control of the langerin promoter, which are known as langerineGFP-DTR
mice, 3, 4 and langerin-DTR mice. 6-8 In these knock-in mice, both LCs and langerin-
positive dDCs are detected based on their eGFP expression, and both are completely
depleted by administration of DT. Once depleted, LCs do not repopulate for at least 4 weeks …