[HTML][HTML] Dietary zinc restriction and repletion affects DNA integrity in healthy men
Background: Zinc plays an important role in antioxidant defense and the maintenance of
cellular DNA integrity. However, no experimental human studies have been performed to
examine the role of zinc status on DNA damage. Objective: We evaluated the effects of
dietary zinc depletion and repletion on DNA strand breaks, oxidative stress, and antioxidant
defenses in healthy men. Design: Nine healthy men with reported mean daily zinc intakes>
11 mg/d were recruited. Subjects completed 3 consecutive dietary periods: baseline (days 1 …
cellular DNA integrity. However, no experimental human studies have been performed to
examine the role of zinc status on DNA damage. Objective: We evaluated the effects of
dietary zinc depletion and repletion on DNA strand breaks, oxidative stress, and antioxidant
defenses in healthy men. Design: Nine healthy men with reported mean daily zinc intakes>
11 mg/d were recruited. Subjects completed 3 consecutive dietary periods: baseline (days 1 …