The neonate-6-hydroxydopamine-lesioned rat: a model for clinical neuroscience and neurobiological principles
GR Breese, DJ Knapp, HE Criswell, SS Moy… - Brain research …, 2005 - Elsevier
In 1973, a technique of administering 6-hydroxydopamine (2, 4, 5-
trihydroxyphenylethylamine) intracisternally to neonate rats was introduced to selectively
reduce brain dopamine (neonate-lesioned rat). This neonate treatment proved unique when
compared to rats lesioned as adults with 6-hydroxydopamine—prompting the discovery of
differing functional characteristics resulting from the age at which brain dopamine is
reduced. A realization was that neonate-lesioned rats modeled the loss of central dopamine …
trihydroxyphenylethylamine) intracisternally to neonate rats was introduced to selectively
reduce brain dopamine (neonate-lesioned rat). This neonate treatment proved unique when
compared to rats lesioned as adults with 6-hydroxydopamine—prompting the discovery of
differing functional characteristics resulting from the age at which brain dopamine is
reduced. A realization was that neonate-lesioned rats modeled the loss of central dopamine …