The transforming growth factor-α and cyclin D1 genes are direct targets of β-catenin signaling in hepatocyte proliferation
C Torre, S Benhamouche, C Mitchell, C Godard… - Journal of …, 2011 - Elsevier
BACKGROUND & AIMS: β-Catenin is an oncogene frequently mutated in hepatocellular
carcinoma. In this study, we investigated target genes of β-catenin signaling in hepatocyte
proliferation. METHODS: We studied transgenic mice displaying either inactivation or
activation of the β-catenin pathway, focusing on analysis of liver proliferation due to aberrant
β-catenin activation, and on the regeneration process during which β-catenin signaling is
transiently activated. We localized in situ the various partners involved in proliferation or …
carcinoma. In this study, we investigated target genes of β-catenin signaling in hepatocyte
proliferation. METHODS: We studied transgenic mice displaying either inactivation or
activation of the β-catenin pathway, focusing on analysis of liver proliferation due to aberrant
β-catenin activation, and on the regeneration process during which β-catenin signaling is
transiently activated. We localized in situ the various partners involved in proliferation or …