‘Stratum Corneum Moisturization At The Molecular Level’[1] was published over a decade ago to review what was known about the biology of a common cosmetic problem called ‘dry skin’(Figure 1). At the same time Warner and Lilly [2] in 1994 published ‘The correlation of water content with ultrastructure in the stratum corneum’and demonstrated for the first time the precise location of the reduced water content of the skin in dry skin conditions, namely the outermost layers of the stratum corneum (SC). These key publications described the current state of the art of dry skin knowledge. Since then significant advances have been made in our understanding of the pathophysiology of dry skin.