Roles for IL-1 and TNFα in dynamic behavioral responses of Langerhans cells to topical hapten application
A Nishibu, BR Ward, M Boes, A Takashima - Journal of dermatological …, 2007 - Elsevier
BACKGROUND: To understand the behavioral biology of Langerhans cells (LCs), we
recently recorded time-lapse images of LCs in the knock-in mice expressing the I-Aβ chain
tagged with the enhanced green fluorescence protein (EGFP). EGFP+ LCs showed
relatively limited motility in the steady state, whereas topical application of
dinitrofluorobenzene (DNFB) markedly augmented a unique movement of dendrites
characterized by rhythmic extension and retraction, termed dSEARCH, and triggered …
recently recorded time-lapse images of LCs in the knock-in mice expressing the I-Aβ chain
tagged with the enhanced green fluorescence protein (EGFP). EGFP+ LCs showed
relatively limited motility in the steady state, whereas topical application of
dinitrofluorobenzene (DNFB) markedly augmented a unique movement of dendrites
characterized by rhythmic extension and retraction, termed dSEARCH, and triggered …