The role of epithelial injury and repair in the origins of asthma
TL Hackett, DA Knight - Current opinion in allergy and clinical …, 2007 - journals.lww.com
Current opinion in allergy and clinical immunology, 2007•journals.lww.com
It is becoming increasingly clear from studies involving adults and, more recently, children,
that the epithelium orchestrates inflammatory and remodeling responses of the airway.
Equally clear is that the asthmatic epithelium responds inappropriately to challenge and
displays signs of dysregulated repair. Understanding the regulatory mechanisms involved in
these processes, including the role of resident/recruited progenitor cells, is crucial if we are
to halt the progression of asthma when the disease first manifests in childhood.
that the epithelium orchestrates inflammatory and remodeling responses of the airway.
Equally clear is that the asthmatic epithelium responds inappropriately to challenge and
displays signs of dysregulated repair. Understanding the regulatory mechanisms involved in
these processes, including the role of resident/recruited progenitor cells, is crucial if we are
to halt the progression of asthma when the disease first manifests in childhood.
Summary
It is becoming increasingly clear from studies involving adults and, more recently, children, that the epithelium orchestrates inflammatory and remodeling responses of the airway. Equally clear is that the asthmatic epithelium responds inappropriately to challenge and displays signs of dysregulated repair. Understanding the regulatory mechanisms involved in these processes, including the role of resident/recruited progenitor cells, is crucial if we are to halt the progression of asthma when the disease first manifests in childhood.
Lippincott Williams & Wilkins