The ARF/p53 pathway
CJ Sherr, JD Weber - Current opinion in genetics & development, 2000 - Elsevier
CJ Sherr, JD Weber
Current opinion in genetics & development, 2000•ElsevierThe ARF tumor suppressor connects pathways regulated by the retinoblastoma protein and
p53. ARF inactivation reduces p53-dependent apoptosis induced by oncogenic signals.
Nucleolar relocalization of Mdm2 by ARF connotes a novel mechanism for preventing p53
turnover and provides a framework for understanding how stress signals cooperate to
regulate p53 function.
p53. ARF inactivation reduces p53-dependent apoptosis induced by oncogenic signals.
Nucleolar relocalization of Mdm2 by ARF connotes a novel mechanism for preventing p53
turnover and provides a framework for understanding how stress signals cooperate to
regulate p53 function.
The ARF tumor suppressor connects pathways regulated by the retinoblastoma protein and p53. ARF inactivation reduces p53-dependent apoptosis induced by oncogenic signals. Nucleolar relocalization of Mdm2 by ARF connotes a novel mechanism for preventing p53 turnover and provides a framework for understanding how stress signals cooperate to regulate p53 function.
Elsevier