[HTML][HTML] Srcasm corrects Fyn-induced epidermal hyperplasia by kinase down-regulation
Src family tyrosine kinases (SFKs) are important regulators of epithelial cell growth and
differentiation. Characterization of cellular mechanisms that regulate SFK activity will provide
insights into the pathogenesis of diseases associated with increased SFK activity. Keratin 14-
Fyn (K14) transgenic mice were derived to characterize the effect of Fyn on epidermal
growth and differentiation in vivo. The epidermis of K14-Fyn mice is thickened, manifests
prominent scale, and exhibits features consistent with hyperproliferation. Increased …
differentiation. Characterization of cellular mechanisms that regulate SFK activity will provide
insights into the pathogenesis of diseases associated with increased SFK activity. Keratin 14-
Fyn (K14) transgenic mice were derived to characterize the effect of Fyn on epidermal
growth and differentiation in vivo. The epidermis of K14-Fyn mice is thickened, manifests
prominent scale, and exhibits features consistent with hyperproliferation. Increased …