Recombinant variant of ciliary neurotrophic factor for weight loss in obese adults: a randomized, dose-ranging study
MP Ettinger, TW Littlejohn, SL Schwartz, SR Weiss… - Jama, 2003 - jamanetwork.com
ContextObese individuals tend to resist the weight-regulating effects of exogenously
administered leptin. A genetically engineered recombinant human variant ciliary
neurotrophic factor (rhvCNTF) that signals through leptinlike pathways in the hypothalamus
has been shown to bypass leptin resistance in animal models of obesity. ObjectiveTo
identify a safe and well-tolerated dose of rhvCNTF that causes weight loss in obese adults.
Design, Setting, and PatientsTwelve-week, double-blind, randomized, parallel-group, dose …
administered leptin. A genetically engineered recombinant human variant ciliary
neurotrophic factor (rhvCNTF) that signals through leptinlike pathways in the hypothalamus
has been shown to bypass leptin resistance in animal models of obesity. ObjectiveTo
identify a safe and well-tolerated dose of rhvCNTF that causes weight loss in obese adults.
Design, Setting, and PatientsTwelve-week, double-blind, randomized, parallel-group, dose …