[HTML][HTML] Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein
PC Schulze, J Yoshioka, T Takahashi, Z He… - Journal of Biological …, 2004 - ASBMB
Increased intracellular reactive oxygen species (ROS) contribute to vascular disease and
pro-atherosclerotic effects of diabetes mellitus may be mediated by oxidative stress. Several
ROS-scavenging systems tightly control cellular redox balance; however, their role in
hyperglycemia-induced oxidative stress is unclear. A ubiquitous antioxidative mechanism for
regulating cellular redox balance is thioredoxin, a highly conserved thiol reductase that
interacts with an endogenous inhibitor, thioredoxin-interacting protein (Txnip). Here we …
pro-atherosclerotic effects of diabetes mellitus may be mediated by oxidative stress. Several
ROS-scavenging systems tightly control cellular redox balance; however, their role in
hyperglycemia-induced oxidative stress is unclear. A ubiquitous antioxidative mechanism for
regulating cellular redox balance is thioredoxin, a highly conserved thiol reductase that
interacts with an endogenous inhibitor, thioredoxin-interacting protein (Txnip). Here we …