Complete weaning off immunosuppression in HCV liver transplant recipients is feasible and favourably impacts on the progression of disease recurrence
G Tisone, G Orlando, A Cardillo, G Palmieri… - Journal of …, 2006 - Elsevier
BACKGROUND/AIMS: HCV-related disease recurrence progresses rapidly after liver
transplantation. We hypothesised that withdrawal of immunosuppression might favourably
impact on disease progression. METHODS: Weaning off immunosuppression was attempted
in 34 HCV–RNA positive patients (mean age 62±6.4 years) transplanted 63.5±20.1 months
earlier, under cyclosporine A monotherapy. Patients were followed for 3 years including
yearly protocol liver biopsies. Primary endpoints were feasibility of weaning off …
transplantation. We hypothesised that withdrawal of immunosuppression might favourably
impact on disease progression. METHODS: Weaning off immunosuppression was attempted
in 34 HCV–RNA positive patients (mean age 62±6.4 years) transplanted 63.5±20.1 months
earlier, under cyclosporine A monotherapy. Patients were followed for 3 years including
yearly protocol liver biopsies. Primary endpoints were feasibility of weaning off …