[PDF][PDF] Stem cell–related “self-renewal” signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy …
A Murat, E Migliavacca, T Gorlia… - Journal of clinical …, 2008 - researchgate.net
A Murat, E Migliavacca, T Gorlia, WL Lambiv, T Shay, MF Hamou, N De Tribolet, L Regli…
Journal of clinical oncology, 2008•researchgate.netPurpose Glioblastomas are notorious for resistance to therapy, which has been attributed to
DNA-repair proficiency, a multitude of deregulated molecular pathways, and, more recently,
to the particular biologic behavior of tumor stem-like cells. Here, we aimed to identify
molecular profiles specific for treatment resistance to the current standard of care of
concomitant chemoradiotherapy with the alkylating agent temozolomide.
DNA-repair proficiency, a multitude of deregulated molecular pathways, and, more recently,
to the particular biologic behavior of tumor stem-like cells. Here, we aimed to identify
molecular profiles specific for treatment resistance to the current standard of care of
concomitant chemoradiotherapy with the alkylating agent temozolomide.
Purpose
Glioblastomas are notorious for resistance to therapy, which has been attributed to DNA-repair proficiency, a multitude of deregulated molecular pathways, and, more recently, to the particular biologic behavior of tumor stem-like cells. Here, we aimed to identify molecular profiles specific for treatment resistance to the current standard of care of concomitant chemoradiotherapy with the alkylating agent temozolomide.
researchgate.net