Apoptosis is meticulously controlled in living organisms. Its dysregulation has been shown to
play a key role in a number of human diseases, including neoplastic, cardiovascular, and
degenerative disorders. Bcl-2 family member proteins and inhibitors of apoptosis proteins
are two major negative regulators of apoptosis. We report here the characterization of novel
antiapoptotic protein, fortilin, which we identified through yeast two-hybrid library screening.
Sequence analysis of fortilin revealed it to be a 172-amino acid polypeptide highly …